05/05/2026
In this study, we developed a mechanistic QSP model to map out B cell activation, differentiation, and migration across lymphoid organs-effectively linking cellular dynamics to antibody production.
While B cells are fundamental to our immune system, their system-level behavior is notoriously complex due to spatial organization and nonlinear dynamics.
Through sensitivity analysis, we identified key drivers of the immune response and explained variability observed across experiments. In particular, moderate changes in parameters governing plasma cell influx into the bone marrow and survival niche availability were sufficient to reproduce high inter-study variability in bone marrow ASC levels, providing a mechanistic explanation for heterogeneity in functional immune responses.
This work is a core part of mission to leverage QSP to deepen our understanding of immune-mediated diseases and advance model-informed drug development.
