A new article was published in Frontiers in Immunology

Azarov, I., Peskov, K., Helmlinger, G., & Kosinsky, Y. (2019). Role of T Cell-To-Dendritic Cell Chemoattraction in T Cell Priming Initiation in the Lymph Node: An Agent-Based Modeling Study. Frontiers in Immunology, 10, 1289. doi: 10.3389/fimmu.2019.01289

The collaborative work of the authors from M&S Decisions and AstraZeneca is devoted to the mechanistic description of the naive T cells activation inside the lymph node’s T-zone and the immune response initiation. The study was carried out using agent-based modeling.

Current research has convincingly shown that the predominant type of motion of naive lymphocytes is random motion. On the other hand, selective chemotaxis motion of activated cognate T cells in the direction of dendritic cells is critical for reproducing the cognate clones expansion and the immune response development.