A new article was published in Pharmaceutics journal  

Vaskeikina, M., Ugolkov, Y., Kireev, B., Peskov, K., & Volkova, A. (2026). Systematic Review and Model-Based Meta-Analysis of Targeted Drugs for Systemic Sclerosis. Pharmaceutics, 18(2), 250.

A new article published in Pharmaceutics journal! This article presents a model-based meta-analysis of targeted therapies in systemic sclerosis (SSc). The study synthesizes data from 32 randomized controlled trials (RCTs), including 2036 patients and 23 targeted agents, to compare treatment effects on skin and lung involvement.

A systematic search of PubMed and ClinicalTrials was conducted to identify eligible RCTs. A longitudinal mixed-effects meta-model incorporating Emax structural functions was developed to characterize response trajectories for the modified Rodnan skin score (mRSS) and forced vital capacity (FVC). Between-study and between-treatment-arm variability were explicitly modeled to account for heterogeneity.

This model-based meta-analysis provides a broad comparison of targeted therapies in SSc, highlighting distinct efficacy patterns for skin versus lung involvement and offering hypothesis-generating insights that may support treatment selection and the design of future clinical trials.