Services
// WE OFFER
Our services
The high versatility of modeling skills represented by M&S Decisions allows us to cover: population PKPD and pharmacometrics, quantitative systems pharmacology (QSP), disease progression modeling, meta-analyses – thereby providing our clients with quantitative companion tools, in support of decision-making across Drug R&D continuum.
Mathematical modeling performed in M&S Decisions
1. Pharmacometrics
- Population pharmacokinetic and pharmacodynamic (PKPD) modeling, Dose-Exposure-Response analysis, disease progression modeling, time-to-event and categorical data analysis, Bayesian modeling, clinical trial simulations, model-based meta-analysis
2. Quantitative Systems pharmacology /
mechanistic modeling
- Target turnover models, target-mediated disposition models, mechanistic disease progression modeling;
- Physiologically-based pharmacokinetic (PBPK) modeling;
- Systems biology modeling: cellular pathway and signal transduction models, biomarker identification aided by context modeling, gene regulatory network models;
- Cell dynamics modeling: cell growth and cell death modeling (bacteria, viruses, tumors), cell cycle and circadian rhythm modeling.
3. Cost-effectiveness modeling, health outcome research and disease burden assessment, decision analysis
