Conferences

V. Sokolov, A. Dolgun, K. Zhudenkov, G. Helmlinger, K. Peskov. Evaluation of MATLAB SimBiology functionality in comparison to other MATLAB and R-based software in the framework of quantitative systems pharmacology model development workflow. 2019 ACOP10 Conference, Orlando, USA.

Sergey Gavrilov, Kirill Zhudenkov, Kirill Peskov, Gabriel Helmlinger, Sergey Aksenov. Evaluation of longitudinal biomarkers associated with survival of prostate cancer patients by means of Bayesian joint modeling. StanCon, 2019, Conference, Cambridge, UK.

B. Shulgin, Yu. Kosinsky, A. Smirnova, K. Peskov, Quantification of dose dependence of immune mediated adverse events of PD 1 and CTLA 4 inhibitors monotherapies and combinations using a Bayesian meta-analysis. StanCon, 2019, Conference, Cambridge, UK.

Kirill Zhudenkov, Robert Palmér, Alexandra Jauhiainen, Gabriel Helmlinger, Oleg Stepanov, Kirill Peskov, Ulf G Eriksson, Ulrika Wählby Hamrén. Longitudinal FEV1 and exacerbation risk in COPD: Quantifying the association using joint modelling. PAGE Meeting, 2019, Stockholm, Sweden.

Sergey Gavrilov, Kirill Zhudenkov, Kirill Peskov, Gabriel Helmlinger, Sergey Aksenov. Longitudinal assessment of tumor size and neutrophil count in multivariate joint models are more predictive of survival than their baseline values in patients with non-small cell lung cancer. PAGE Meeting, 2019, Stockholm, Sweden.

Kirill Zhudenkov, Robert Palmér, Alexandra Jauhiainen, Gabriel Helmlinger, Oleg Stepanov, Kirill Peskov, Ulf G Eriksson, Ulrika Wählby Hamrén. Longitudinal FEV1 and exacerbation risk in COPD: Quantifying the association using joint modelling. PAGE Meeting, 2019, Stockholm, Sweden.

Sergey Gavrilov, Kirill Zhudenkov, Kirill Peskov, Gabriel Helmlinger, Sergey Aksenov. Longitudinal tumor size and NLR are more predictive of individual survival than their baseline values in patients with non-small cell lung cancer treated with durvalumab. 2019 ASCO Annual Meeting, Chicago, USA.

Sergey Gavrilov, Kirill Zhudenkov, Kirill Peskov, Gabriel Helmlinger, Sergey Aksenov. Longitudinal assessment of tumor size and neutrophil count in multivariate joint models are more predictive of survival than their baseline values in patients with non-small cell lung cancer. PAGE Meeting, 2019, Stockholm, Sweden.

Pablo Morentin Gutierrez, Yuri Kosinsky, Kirill Peskov, Ivan Azarov, Lulu Chu, Veronika Voronova, Martin Johnson, Yingxue Chen, Larissa Carnevalli, Danielle Carroll, Michele Moschetta, Teresa Klinowska, Gabriel Helminger. Mechanistic insights and dose optimization for AZD3458, a novel selective PI3Kʏ immuno-modulator, using a quantitative systems approach. Annual Meeting of American Association of Cancer Research 2019, Atlanta, USA.

Sergey Gavrilov, Kirill Zhudenkov, Kirill Peskov, Gabriel Helmlinger, Sergey Aksenov. Longitudinal tumor size and NLR are more predictive of individual survival than their baseline values in patients with non-small cell lung cancer treated with durvalumab. 2019 ASCO Annual Meeting, Chicago, USA.

Ivan Azarov, Yury Kosinsky, Veronika Voronova, Lulu Chu, Suzanne I.S. Sitnikova, Simon Dovedi, Kirill Peskov, Gabriel Helminger. Linking tumor microenvironment properties in murine syngeneic tumors with resistance to immune checkpoint inhibitors: Insights from a quantitative systems approach. Annual Meeting of American Association of Cancer Research 2019, Atlanta, USA.

Veronika Voronova, Victor Sokolov, Dina Chernikova, Amani Al-Khaifi, Sara Straniero, Chanchal Kumar, Kirill Peskov, Gabriel Helmlinger, Mats Rudling, Bo Angelin. A physiology-based model of the distribution of individual bile acids within the enterohepatic circulation under normal and pathological conditions in human. XXV International Bile Acid Meeting: Bile Acids in Health and Disease 2018, Dublin, Ireland.

Victor Sokolov, Tatiana Yakovleva, Shinya Ueda, Joanna Parkinson, Robert C. Penland, David W. Boulton, Weifeng Tang. Dapagliflozin Exposure–Response in Japanese vs Non-Japanese Patients with Type 1 Diabetes. 78th Scientific Sessions of American Diabetes Association, Orlando, USA.

V Voronova, K Zhudenkov, R C. Penland, D W. Boulton, G Helmlinger, K Peskov. Exenatide effects on gastric emptying and oral glucose appearance in plasma: A quantitative assessment using an integrative systems pharmacology model. 9th American Conference on Pharmacometrics (ACoP9), San-Diego, USA.

Victor Sokolov, Artem Dolgun, Kirill Zhudenkov, Henning Schmidt, Gabriel Helmlinger, Kirill Peskov. Evaluation of the utility of a MATLAB and R-based workflow for the development of quantitative systems pharmacology (QSP) models. 9th American Conference on Pharmacometrics (ACoP9), San-Diego, USA.

Yuri Kosinsky, Ivan Azarov, Lulu Chu, Gabriel Helmlinger, Kirill Peskov, Sergey Aksenov. Comparison of different approaches to modeling early tumor size dynamics for accurate prediction of survival in non-small cell lung cancer (NSCLC) clinical trials. 9th American Conference on Pharmacometrics (ACoP9), San-Diego, USA.

Kirill Zhudenkov, Oleg Stepanov, Ulf Eriksson, Robert Palmér, Alexandra Jauhiainen, Kirill Peskov, Gabriel Helmlinger, Ulrika Wählby Hamrén. Quantification of lung function and risk of COPD exacerbation association to predict long-term effects for new treatment arms using a drug-differentiated joint model. 9th American Conference on Pharmacometrics (ACoP9), San-Diego, USA.

Veronika Voronova, Lulu Chu, Yuri Kosinsky, Alexandra Borodovsky, Richard Woessner, Kris Sachsenmeier, Ganesh Mugundu, Melinda Merchant, Wenlin Shao, Kirill Peskov, Gabriel Helmlinger. Anti-tumor synergy evaluation of an AZD4635/ anti-PD-L1 combination therapy using a quantitative systems model. The Society for Immunotherapy of Cancer Annual Meeting, Washington D.C., USA.

Yuri Kosinsky, Simon Dovedi, Kirill Peskov, Veronika Voronova, Lulu Chu, Don Stanski, Gabriel Helmlinger. Immune cell responses and dose scheduling optimization of radiation and anti-PD-L1 treatment combination using a joint experimental and systems modeling approach. The Society for Immunotherapy of Cancer Annual Meeting, Washington D.C., USA.

Boris Shulgin, Yuri Kosinsky, Andrey Omelchenko, Lulu Chu, Ganesh Mugundu, Garrett DeYulia, Rodrigo Pimentel, Kirill Peskov, Gabriel Helmlinger. Characterizing immune-mediated adverse events of anti-PD-1 and anti-CTLA-4 monotherapies and combinations using a quantitative model based meta-analysis. The Society for Immunotherapy of Cancer Annual Meeting, Washington D.C., USA.

Victor Sokolov, Eva Hurt-Camejo, Catarina Nilsson, Kirill Zhudenkov, Stanko Skrtic, Bengt Hamrén, Kirill Peskov, Gabriel Helmlinger, Rasmus Jansson-Löfmark (2018) Differentiation of anti-PCSK9 antibodies and synthesis inhibitors: a drug-disease modeling study. ASCPT 2018 Annual Meeting, Orlando, FL, USA.

Tatiana Yakovleva, Victor Sokolov, Lulu Chu, Robert C. Penland, Weifeng Tang, Peter J. Greasley, Susanne Johansson, Kirill Peskov, Gabriel Helmlinger, David W. Boulton (2018) Contribution and regulation of SGLT1 and SGLT2 in healthy and type 2 diabetes subjects: a drug-disease modeling study. ASCPT 2018 Annual Meeting, Orlando, FL, USA.

Artem Dolgun, Victor Sokolov, Henning Schmidt, Nidal Al-Huniti, Gabriel Helmlinger, Kirill Peskov (2018) A functional, integrative R environment workflow for the development and use of quantitative systems pharmacology models. PAGE 2018 Conference, Montreux, Switzerland.

Veronika Voronova, Victor Sokolov, Dina Chernikova, Amani Al-Khaifi, Sara Straniero, Chanchal Kumar, Kirill Peskov, Gabriel Helmlinger, Mats Rudling, Bo Angelin (2018) Using a physiologically-based QSP model to simulate the effects of enterohepatic circulation perturbations on the distribution of bile acids. PAGE 2018 Conference, Montreux, Switzerland.

Kosinsky Yu, Chu L, Peskov K, Voronova V, Borodovsky A, Woessner R, Sachsenmeier K, Al-Huniti N, Helmlinger G. (2018) Quantitative modeling as a systematic approach for drug combination evaluation in Immuno-Oncology. AACR 2018 annual meeting, Chicago, USA.

Kosinsky, Y., Dovedi, S., Peskov, K., Voronova, V., Chu, L., Tomkinson, H., Al-Huniti, N., Stanski, D., & Helmlinger, G. (2017) Radiation and anti-PD-L1 treatment combinations: Immune cell responses and dose scheduling optimization using a joint experimental and systems modeling approach. PKUK 2017 Meeting, Great Malvern, UK.

Abdallah, K., Shulgin, B., Peskov, K., Kosinsky, Y., Vergara-Silva, A., Helmlinger, G., Chu, L., & Masson, G. (2017) Model-based meta-analysis of safety for immune checkpoint inhibitor combinations and monotherapy, ASCO-SITC Clinical Immuno-Oncology Symposium, Orlando, USA.

Kosinsky, Y., Dovedi, S., Peskov, K., Voronova, V., Chu, L., Masson, E., Tomkinson, H., Al-Huniti, N., Stanski, D., & Helmlinger, G. (2017) Radiation and anti-PD-L1 treatment combinations: Immune cell responses and dose scheduling optimization using a joint experimental and systems modeling approach. Abstracts of the Annual Meeting of the Population Approach Group in Europe (PAGE), Budapest, Hungary, ISSN 1871-6032.

Chernikova, D., Sokolov, V., Voronova, V., Al-Khaifi, A., Straniero, S., Rudling, M., Kumar, C., Peskov, K., Helmlinger, G., & Angelin, B. (2017) Inhibition of bile acids synthesis via fibroblast growth factor 19 (FGF19) through intestinal signaling: A population analysis. Abstracts of the Annual Meeting of the Population Approach Group in Europe (PAGE), Budapest, Hungary, ISSN 1871-6032. 

Onishchenko, D., Dunyak, J., Helmlinger, G., Masson, E., Tomkinson, H., Peskov, K., & Al-Huniti, N. (2017) Joint modeling of overall survival and tumor size dynamics in non-small cell lung cancer: Clinical trial simulations and validation of predictions at study and subject levels. Abstracts of the Annual Meeting of the Population Approach Group in Europe (PAGE), Budapest, Hungary, ISSN 1871-6032. 

Voronova, V., Zhudenkov, K., Penland, R. C., Boulton, D. W., Helmlinger, G., & Peskov, K. (2017) Evaluation of immediate release exenatide effects on gastric motility and intestinal glucose absorption using a systems pharmacology model. Abstracts of the Annual Meeting of the Population Approach Group in Europe (PAGE), Budapest, Hungary, ISSN 1871-6032.

Kosinsky, Y., Peskov, K, Voronova, V, Chu, L., Al-Huniti, N., Masson, E., & Helmlinger, G. (2017) Quantitative Systems Pharmacology (QSP) modeling as a systematic approach for drug combination evaluation in Immuno-Oncology (IO). 8th American Conference on Pharmacometrics (ACoP8), Fort Lauderdale, USA.

Sokolov, V., Chu, L., Kosinski, Y., Al-Huniti, N., Fox, R., Schmidt, H., Onishchenko, D., Voronova, , Zhudenkov, K., Helmlinger, G., & Peskov, K. (2017) Drug-Disease modeling: a practical workflow from model development to simulations. 8th American Conference on Pharmacometrics (ACoP8), Fort Lauderdale, USA.

Sokolov, V., Goncharov, A., Hurt-Camejo, E., Nilsson, C., Zhudenkov, K., Skrtic, S., Hamrén, B., Peskov, K., Helmlinger, G., Jansson-Löfmark, R. (2017) Differentiation of anti-PCSK9 antibodies and synthesis inhibitors using Drug-Disease modeling of lipoprotein metabolism. 8th American Conference on Pharmacometrics (ACoP8), Fort Lauderdale, USA.

Yakovleva, T., Sokolov, V., Chu, L., Penland, R. C., Tang, W., Greasley, P. J., Johansson, S., Peskov, K., Helmlinger, G., & Boulton, D. W. (2017) Drug-disease modeling of renal glucose reabsorption in healthy and diabetes subjects: Investigating differences in SGLT2 inhibitors pharmacodynamics. 8th American Conference on Pharmacometrics (ACoP8), Fort Lauderdale, USA.

Zhudenkov, K., Chernikova, D., Onishchenko, D., Al-Huniti, N., Peskov, K., Helmlinger, G., Eriksson, U., Palmer, R., & Jauhiainen, A. (2017) Dynamic prediction of treatment response and probability of exacerbation in COPD using joint modeling. 8th American Conference on Pharmacometrics (ACoP8), Fort Lauderdale, USA.

Al-Huniti, N., Onishchenko, D., Xu, H., Zhou, D., Masson, E., Helmlinger, G., Tomkinson, H., Abdallah, & K., Dunyak, J. (2017) Dynamic prediction of pregression free survival (PFS) and overall survival (OS) in non-small cell lung cancer (NSCLC) using tumor size: A longitudinal joint modeling approach. ASCPT meeting, Washington D.C., USA.

Sokolov, V., Hurt-Camejo, E., Nilsson, C., Zhudenkov, K., Skrtic, S., Hamren, B., Peskov, K., Helmlinger, G., & Jansson-Lofmark, R. (2017) Properties of Anti-PCSK9 Antibodies and Synthesis Inhibitors Using a Quantitative Systems Model of Lipoprotein Metabolism. American Diabetic Association (ADA) scientific sessions, San Diego, California.

Voronova, V., Sokolov, V., Al-Khaifi, A., Straniero, S., Rudling, M., Chanchal, K., Peskov, K., Helmlinger, G., & Angelin, B. (2017) Systems Pharmacology Modeling of Bile Acid Distribution and Signaling in Humans. Keystone symposia: Bile Acid Receptors as Signal Integrators in Liver and Metabolism, Monterey, USA.

Kosinsky, K., Peskov, K., Shulgin, B., Stepanov, O., Voronova, V., Masson, E., & Helmlinger, G. (2016) Investigation of anti-CTLA-4 immuno-oncology therapy through a quantitative systems pharmacology model. Abstracts of the Annual Meeting of the Population Approach Group in Europe (PAGE), Lisbon, Portugal.

Sokolov, S., Yakovleva, T., Zhudenkov, K., Mercier, A-K., Helmlinger, G., Peskov, K., & Eriksson, U. (2016) A mechanistic PKPD model relating early asthmatic response to anti-leukotriene drug PK and biomarker levels in allergen challenge studies. Abstracts of the Annual Meeting of the Population Approach Group in Europe (PAGE), Lisbon, Portugal. 

Stepanov, O., Voronova, V., Kosinsky, Y., Peskov, K., Masson, E., & Helmlinger, G. (2016) A quantitative systems pharmacology model to explore combination efficacy of immuno-oncology compounds: Effects of CXCR2 and PD-1 inhibitions. Abstracts of the Annual Meeting of the Population Approach Group in Europe (PAGE), Lisbon, Portugal. 

Voronova, V., & Zhudenkov, K. (2016) Investigation of the diabetes-related metabolic memory phenomenon using a quantitative systems pharmacology approach. Abstracts of the Annual Meeting of the Population Approach Group in Europe (PAGE), Lisbon, Portugal.

Yakovleva, T., Sokolov, V., & Zhudenkov, K. (2016) A systems pharmacology model of SGLT2 and SGLT1 inhibition to understand mechanism and quantification of urinary glucose excretion after treatment with Dapagliflozin, Canagliflozin and Empagliflozin. Abstracts of the Annual Meeting of the Population Approach Group in Europe (PAGE), Lisbon, Portugal. 

Kosinsky, Y., Peskov, K., Shulgin, B., Stepanov, O., Voronova, V., Masson, E., & Helmlinger, G. (2016) Quantitative Systems Pharmacology model for immuno-oncology drug development: example of CTLA4 inhibition mechanism. International Conference on Systems Biology (ICSB), Barcelona, Spain.

Peskov, K., Stepanov, O., Voronova, V., Kosinsky, Y., Masson, E., & Helmlinger, G. (2016) A quantitative systems pharmacology model to explore combination efficacy of immuno-oncology compounds: Effects of CXCR2 and PD-1 inhibitions. International Conference on Systems Biology (ICSB), Barcelona, Spain.

Shulgin, B., Helmlinger, G., & Kosinsky, Y. (2016) Enchancement of cytokine signaling via cytokine-neutralizing antibodies, International Conference on Systems Biology (ICSB), Barcelona, Spain.

Girnyk, A., Omelchenko, A., Vergun, A., & Ryskov A. (2016) Genetic and clonal variation in the D. armeniaca. Book of Abstracts of 9th Symposium on the Lacertids of the Mediterranean Basin & 1st Symposium, Lemesos (Limassol), Cyprus, 55.

Dolgun, A., & Myslivets, A. (2016) Universal SAS® macro for generating Statistical Analysis Report in one click for I-IV phase Clinical Trials. Annual Conference of the International Society for Clinical Biostatistics (ISCB), Birmingham, UK

Voronova, V., Karelina, T., Demin, O., & Chen, D. (2015) Understanding of GFR (Glomerular Filtration Rate) Changes in Response to ARB Administration using a Quantitative Systems Pharmacology Approach. ASCPT meeting, Indianapolis, USA.

Yakovleva, T., Demin, O. Jr., & Demin, O. (2015) Evaluation of minimum threshold hepatitis C virus concentration in plasma required for disease development. The 12th congress of EACPT.

Yakovleva, T., Demin, O. Jr., & Demin, O. (2015) The systems pharmacology model of hepatitis C progression and treatment. ASCPT meeting, Indianapolis, USA.

Yakovleva, T., Demin, O. Jr., & Demin, O. (2015) The systems pharmacology model of hepatitis C progression: evaluation of minimal viral concentration required for disease development. The 15th International Symposium on Viral Hepatitis and Liver Disease (ISVHLD).

Caputo, A., &Peskov, K. (2014) Modeling Alzheimer’s Disease Progression Using the CDR Sum of Boxes Data from ADNI and in-house clinical data. Novartis Biostatistics conference, Basel, Switzerland.

Dua, P., Demin, O. Jr., Sokolov, V., Yakovleva, T., Demin, O., & Van der Graaf, P. (2014) A systems pharmacology model of purine metabolism to explore novel options for the treatment of Gout. Systems Pharmacology in Drug Discovery & Development, Noordwijkerhout, Netherlands.

Voronova, V., Demin, O. Jr., Smirnov, S., & Demin, O. (2014) Development and Application of Systems Pharmacology Model to Predict Nausea Resulted from Administration of GLP-1 Analogues. ASCPT meeting, Indianapolis, USA.

Yakovleva, T., Demin, O. Jr., & Demin, O. (2014) Investigation of Dapagliflozin inhibition effect on glucose reabsorption using systems pharmacology approach. ASCPT Annual Meeting.

Chen, D., Voronova, V., Smirnov, S., Goryacheva, E., Bakhmutova, A., & Demin, O. (2013) Development of Human System Pharmacology model to Characterize Diabetic Nephropathy Disease Progression and the Effect of Standard of Care Therapy. ACoP meeting, Fort Lauderdale, USA.

Kosinsky, Y., Peskov, K., Popenko, A., Tyakht, A., & Alexeev, D. (2013) Modeling of short-chain fatty acids metabolism in human gut: reconstruction of possible relations between microbiota composition and type 2 diabetes status. International Conference on Systems Biology (ICSB), Copenhagen, Denmark.

Shulgin B., Ebling B., Machacek M., Data integration and PKPD modeling to support differentiation of a novel IL-10 Fc compound against hrIL-10, Science and Innovation Day, Novartis, Basel, 2013

Peskov, K., Kosinsky, Yu., Popenko, A., Tyakht, A., & Alexeev, D. (2012) Mechanistic modeling approach relating human gut microbial community to physiologically-relevant biomarkers. Population Approach Group Europe meeting (PAGE), Venice, Italy. 

Zhudenkov, K., Helmlinger, G., & Schmidt, H. (2012) Application of the SBTOOLBOX2 in drug discovery and development. Population Approach Group Europe meeting (PAGE), Venice, Italy. 

Karelina, T., Kazimirova, E., Zhudenkov, K., Demin, O. Jr, Lu, Y., Nicholas, T., Duvvuri, S., & Barton, H. A. (2012) Kinetic Model of Amyloid Beta Distribution and Allometric Scaling from Mouse to Monkey and Human. Population Approach Group Europe meeting (PAGE), Venice, Italy.

Nicholas, T., Barton, B., Lu, Y., Duvvuri, S., Karelina, T., Demin, O.,  Zhudenkov, K., Belykh, S., Demin, & O. Jr. (2012) Beta-amyloid aggregation human systems pharmacology modeling: Development and application to pharmacological targets in Alzheimer’s disease. Alzheimer’s Association International Conference.

Zhudenkov, K., Vinogradova, S., & Karelina, T. (2011) Pharmacokinetics of PEG-IFN Alpha in HCV Infected Patients. Abstracts of the Annual Meeting of the Population Approach Group in Europe (PAGE).  

Peskov, K., Demidenko, A., Dorodnov, A., Demin, O., & Agoram, B. (2011) A Quantitative Systems Pharmacology Model Provides Insights into Phosphate Homoeostasis through Multiple Interacting Pathways. Population Approach Group Europe meeting (PAGE), Athens, Greece.

Peskov, K., Demidenko, A., Dorodnov, A., Demin, O., Nowlin, D., Kraynov, E., & Luu, K. (2011) System Modeling of EphB4/ephrinB2 Signaling Pathways. Population Approach Group Europe meeting (PAGE), Athens, Greece. 

Demidenko, A.,Peskov, K., Dorodnov, A., Demin, O., Nowlin, D., Kraynov, E., & Luu, K. (2011) System Modeling of EphB4/ephrinB2 Signaling Pathways. International Conference on Systems Biology (ICSB), Heidelberg/Mannheim, Germany

Svetlichny, D., Peskov, K., Demidenko, A., Demin, O., Kraynov, E., & Spilker, M. (2011) Systems modeling of integrin avb3 signaling pathway. International Conference on Systems Biology (ICSB), Heidelberg/Mannheim, Germany.

Omelchenko, A. V., Vergun, A. A., Petrosyan, V. G., & Tokarskaya, O. N. (2011) Models of molecular genetic structures of populations of D. unisexualis on the basis of molecular marking of the genomes. Proceedings of the International conference “Biological diversity and conservation problems”, Yerevan, Armenia, 224 — 227.

Karelina, T., Demin, O., Zhudenkov, K., Svetlichny, D., Demin, O. Jr., Fairman, D., & Agoram, B. (2010) Can systems modeling approach be used to understand complex PK-PD relationships? A case study of 5-lipoxygenase inhibition by zileuton. Abstracts of the Annual Meeting of the Population Approach Group in Europe (PAGE).

Pedentchouk, N., Peskov, K., Borland, A., Cartlidge, L., & Wagner, T. (2010) What causes Differences in 13C/12C and D/H Composition of n-Alkanes from Leaf Waxes among Higher Terrestrial Plants? Stable Isotopes and Biogeochemical Cycles in Terrestrial Ecosystems Conference, Ascona, Switzerland.