Yan-ou Yang, Victor Sokolov, Alina Volkova, Xing Liu, Cristina Leon, Yuri Kosinsky, Breann Barker, Xuecheng Zhang, Peter Ordentlich, Jennifer Sheng, Xuejun Chen. Semimechanistic Population PK/PD Modeling of Axatilimab in Healthy Participants and Patients With Solid Tumors or Chronic Graft-Versus-Host Disease. Clinical Pharmacology and Therapeutics. 20 December 2024. doi: 10.1002/cpt.3503

A. Petrov, I. Makarenko, B. Belova, A. Melikyan, V. Saparova, K. Peskov, N. Kudryashova, V. Kovalik, M. Gefen, A. Khokhlov, R. Drai. (2024) Optimization of Romiplostim Biosimilar Efficacy Trial Using In Silico Clinical Trial Approach for Patients With Immune Thrombocytopenia. Clin Pharmacol Drug Dev. Accepted on Dec 19, 2024.

M&S Decisions participated in the 66th ASH annual meeting, San Diego, California

M&S Decisions participated in the 15th ACOP Meeting, Phoenix, AZ

Olga Ivanova, Michael Pratta, Ivan Azarov, Kirill Zhudenkov, Yuri Kosinsky, Kirill Peskov, Xuejun Chen, Jennifer Sheng. Evaluation of Itacitinib Impact on TNFα Levels Following Immune Effector Cell (IEC) Therapy Using PKPD Modeling and Simulation Approaches. Blood (2024) 144 (Supplement 1): 7129. doi: 10.1182/blood-2024-199649

M&S Decisions participated in the 36th EORTC-NCI-AACR SYMPOSIUM, Barcelona, Spain 

M&S Decisions participated in the IAPC-9 International Meeting, Shanghai, China

Nataliya Kudryashova, Boris Shulgin, Nikolai Katuninks, Victoria Kulesh, Gabriel Helmlinger, Kirill Zhudenkov, Kirill Peskov. Assessment of NSCLC disease burden: A survival model-basedmeta-analysis study. Comput Struct Biotechnol J. 2024 Sep 21:24:611-621. doi: 10.1016/j.csbj.2024.09.012

M&S Decisions participated in the Thirty-second PAGE 2024 Conference

A new article was published in Frontiers in Immunology

Antonina Nikitich, Gabriel Helmlinger, Kirill Peskov, Gennady Bocharov. Mathematical modeling of endogenous and exogenously administered T cell recirculation in mouse and its application to pharmacokinetic studies of cell therapies. Front. Immunol., Sec. T Cell Biology, Volume 15 – 2024.

Yaroslav Ugolkov, Antonina Nikitich, Cristina Leon, Gabriel Helmlinger, Kirill Peskov, Victor Sokolov, Alina Volkova. Mathematical modeling in autoimmune diseases: from theory to clinical application. Front. Immunol., 14 March 2024, Sec. Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders.

A new article was published in Frontiers in Immunology, section Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Victoria Kulesh, Kirill Peskov, Gabriel Helmlinger, Gennady Bocharov. An integrative mechanistic model of thymocyte dynamics. Front. Immunol., Sec. Systems Immunology, Volume 15 – 2024.

A new article was published in Frontiers in Immunology, section Systems Immunology

A new article was published in Frontiers in Cardiovascular Medicine

Alina Volkova, Boris Shulgin, Gabriel Helmlinger, Kirill Peskov, Victor Sokolov. Optimization of the MACE endpoint composition to increase power in studies of lipid-lowering therapies—a model-based meta-analysis. Front. Cardiovasc. Med., Sec. Cardiovascular Epidemiology and Prevention.

Igor Makarenko, Aleksandr Petrov, Bella Belova, Valeria Saparova, Anna Arefeva, Kirill Peskov, Nataliya Kudryashova, Alexandr Khokhlov, Roman Drai. Population Pharmacokinetic and Pharmacodynamic Modeling of Romiplostim Biosimilar GP40141 and Reference Product in Healthy Volunteers to Evaluate Biosimilarity. Clin Pharmacol Drug Dev. 2024 Apr;13(4):419-431.

Kulesh, I. Vasyutin, A. Volkova, K. Peskov, H. Kimko, R. Alluri (2023) A tutorial for model-based evaluation and translation of cardiovascular safety in preclinical trials. CPT Pharmacometrics Syst Pharmacol. 2023; Accepted on 10th Nov.

A new article was published in CPT Pharmacometrics & Systems Pharmacology

A new article was published in Frontiers in Pharmacology

Sokolov V, Yakovleva T, Penland RC, Boulton DW and Tang W (2023) Effectiveness of dapagliflozin as an insulin adjunct in type 1 diabetes: a semi-mechanistic exposure-response model. Front. Pharmacol. 14:1229255. doi: 10.3389/fphar.2023.1229255

Tatiana Safronova, Anna Kravtsova, Sergei Vavilov, Cristina Leon, Anna Bragina, Victor Milyagin, Ruslan Makiev, Alexei Sumin, Kirill Peskov, Victor Sokolov, Valery Podzolkov. Model-Based Assessment of the Reference Values of CAVI in Healthy Population and Benchmarking With CAVI0. Am J Hypertens. 2024 Jan 1;37(1):77-84.

M&S Decisions participated in the AACR Annual meeting 2023

A new article was published in CPT: Pharmacometrics & Systems Pharmacology

A new article was published in Frontiers in Oncology journal

Rekić D., Azarov I., Knöchel J., Sokolov V., Nilsson C., Wernevik L., Han D., Rydén-Bergsten T., Ebrahimi A., Dota C., Carlsson B. AZD8233 Antisense Oligonucleotide targeting PCSK9 does not prolong QT interval AZD8233. British Journal of Clinical Pharmacology, 88(11), 4839-4844. doi: 10.1111/bcp.15425

Kosinsky Y, Peskov K, Stanski DR, Wetmore D, Vinetz J. Semi-Mechanistic Pharmacokinetic-Pharmacodynamic Model of Camostat Mesylate-Predicted Efficacy against SARS-CoV-2 in COVID-19. Microbiol Spectr. 2022 Apr 27;10(2):e0216721. doi: 10.1128/spectrum.02167-21

A new article was published in Frontiers in Pharmacology journal

Karatza E., Yakovleva T., Adams K., Rao GG., Ait-Oudhia S., 2022. Knowledge dissemination and central indexing of resources in pharmacometrics: an ISOP education working group initiative. J Pharmacokinet Pharmacodyn. 2022 Apr 26. doi: 10.1007/s10928-022-09809-9

Victoria S. Kulesh, PharmD1,2, Roman V. Drai, MD, PhD1, Bella R. Zinnatulina, MSc1, Igor E. Makarenko, MD, PhD1, Fedor G. Pilyus, MSc2, and Alexander L. Khokhlov, MD, PhD3. Modeling of Pharmacokinetic Profiles of Insulin Aspart and Biphasic Insulin Aspart 30/70. The Journal of Clinical Pharmacology 2022, 0(0) 1–8, 2022, The American College of Clinical Pharmacology. doi: 10.1002/jcph.2049

Leon, C., Tokarev, A. A., & Volpert, V. A. (2022). Modelling of cytokine storm in respiratory viral infections. Computer Research and Modeling, 14(3), 619–645. doi: 10.1007/s10928-022-09809-9

Leon, C., Kutsenko, I., & Volpert, V. (2022). Existence of solutions for a nonlocal reaction-diffusion equation in biomedical applications. Israel Journal of Mathematics, 248(1), 67–93. doi: 10.1007/s11856-022-2294-6

M&S Decisions participated at the Thirtieth PAGE 2022 Conference

Voronova V, Cullberg M, Delff P, Parkinson J, Dota C, Schiavon G, Maroj B, Rekić D, Cheung SYA. Concentration-QT modelling shows no evidence of clinically significant QT interval prolongation with capivasertib at expected therapeutic concentrations. Br J Clin Pharmacol. 2022 Feb;88(2):858-864. doi: 10.1111/bcp.15006

Chan, P., Peskov, K. & Song, X. Applications of Model-Based Meta-Analysis in Drug Development. Pharm Res (2022). doi: 10.1007/s11095-022-03201-5

Zhudenkov K, Gavrilov S, Sofronova A, et al. A workflow for the joint modeling of longitudinal and event data in the development of therapeutics: Tools, statistical methods, and diagnostics. CPT Pharmacometrics Syst Pharmacol. 2022;00:1-13. doi: 10.1002/psp4.12763

A new article was published in Journal of Pharmacokinetics and Pharmacodynamics.

A workflow for the joint modeling of longitudinal and event data in the development of therapeutics: Tools, statistical methods, and diagnostics

M&S Decisions participated in the World Conference on Pharmacometrics (WCoP 2022), hybrid meeting.

Kirill Zhudenkov, Robert Palmér, Alexandra Jauhiainen, Gabriel Helmlinger, Oleg Stepanov, Kirill Peskov, Ulf G Eriksson, Ulrika Wählby Hamrén. Longitudinal FEV1 and Exacerbation Risk in COPD: Quantifying the Association Using Joint Modelling. International Journal of Chronic Obstructive Pulmonary Disease 16 (2021): 101. doi: 10.2147/COPD.S284720

Genovese MC, Durez P, Fleischmann R, Tanaka Y, Furst D,  Yamanaka H, Korneva E, Vasyutin I, Takeuchi T. Long-term safety and efficacy of olokizumab in patients with rheumatoid arthritis and inadequate response to tumor necrosis factor inhibitor therapy in phase II studies. Eur J Rheumatol. 2021 Jul;8(3):120-129. doi: 10.5152/eurjrheum.2021.19207

M&S Decisions attended the American Conference on Pharmacometrics (ACoP12 2021) held online.

Vasyutin I, Butnaru D, Lyundup A, et al. Frontiers in urethra regeneration: current state and future perspective. Biomed Mater. 2021 Mar 9;16(4). doi: 10.1088/1748-605X/ab99d2

Voronova Veronika, Peskov Kirill, Kosinsky Yuri, Helmlinger Gabriel, Chu Lulu, Borodovsky Alexandra, Woessner Richard, Sachsenmeier Kris, Shao Wenlin, Kumar Rakesh, Pouliot Gayle, Merchant Melinda, Kimko Holly, Mugundu Ganesh. Evaluation of Combination Strategies for the A2AR Inhibitor AZD4635 Across Tumor Microenvironment Conditions via a Systems Pharmacology Model. Front. Immunol., 02 March 2021. doi: 10.3389/fimmu.2021.617316

Leon, C. (2021). Reaction–Diffusion Model of Coexistence of Viruses in the Space of Genotypes. Smart Modelling For Engineering Systems, 265–276. doi: 10.1007/978-981-33-4709-0_22

Shah M., Stolbov L., Yakovleva T., Tang W., Penland RC., Sokolov V., Boulton DW., Parkinson J., 2021. A model-based approach to investigating the relationship between glucose-insulin dynamics and dapagliflozin treatment effect in patients with type 2 diabetes. Diabetes Obes Metab. 2021 Jan 10. doi: 10.1111/dom.14305

Sergey Gavrilov, Kirill Zhudenkov, Gabriel Helmlinger, James Dunyak, Kirill Peskov, Sergey Aksenov. Longitudinal Tumor Size and Neutrophil-to-Lymphocyte Ratio Are Prognostic Biomarkers for Overall Survival in Patients With Advanced Non-Small Cell Lung Cancer Treated With Durvalumab. CPT: Pharmacometrics & Systems Pharmacology. 2020. doi: 10.1002/psp4.12578

A new article was published in Frontiers in Immunology journal.

Veronika Voronova, Svetlana Lebedeva, Marina Sekacheva, Gabriel Helmlinger and Kirill Peskov. Quantification of Scheduling Impact on Safety and Efficacy Outcomes of Brain Metastasis Radio- and Immuno-Therapies: A Systematic Review and Meta-Analysis. Front. Oncol., 02 September 2020. doi: 10.3389/fonc.2020.01609

B Shulgin, A Smirnova, Yu Kosinsky, G Helmlinger, K Peskov, Comparative quantitative safety profiles of PD-1 and PD-L1 checkpoint inhibitor monotherapies: A Bayesian model-based meta-analysis. ASCO Annual Meeting, 2020, Journal of Clinical Oncology 38 (15_suppl), e15167, 2020

A new article was published in CPT: Pharmacometrics & Systems Pharmacology.

L. Stolbov, D. Druzhilovskiy, A. Rudik, D. Filimonov, V. Poroikov, M. Nicklaus. AntiHIV-Pred: Web-resource for in silico prediction of anti-HIV/AIDS activity. Bioinformatics, Volume 36, Issue 3, 1 February 2020, Pages 978–979. doi: 10.1093/bioinformatics/btz638

B Shulgin, Yu Kosinsky, A Smirnova, G Helmlinger, K Peskov, Quantification of dose dependence and frequency of checkpoint inhibitor immune-mediated adverse events: A Bayesian model-based meta-analysis, ASCO-SITC 2020, Journal of Clinical Oncology 38, (5_suppl), 83, 2020

Boris Shulgin , Yuri Kosinsky, Andrey Omelchenko, Lulu Chu, Ganesh Mugundu, Sergey Aksenov, Rodrigo Pimentel, Garrett DeYulia, Geoffrey Kim, Kirill Peskov & Gabriel Helmlinger. Dose dependence of treatment-related adverse events for immune checkpoint inhibitor therapies: a model-based meta-analysis, OncoImmunology, 2020 May 21;9(1):1748982, doi: 10.1080/2162402X.2020.1748982

Diagnostic value of combinatorial markers in colorectal carcinoma

L. Stolbov, D. Druzhilovskiy, D. Filimonov, M. Nicklaus and V. Poroikov. (Q)SAR models of HIV-1 proteins inhibition by drug-like compounds. Molecules. 2020 Jan; 25(1): 87. doi: 10.3390/molecules25010087

A new article was published in Pharmaceuticals journal

Goltsov, A.; Swat, M.; Peskov, K.; Kosinsky, Y. Cycle Network Model of Prostaglandin H Synthase-1. Pharmaceuticals 2020, 13, 265. doi: 10.3390/ph13100265

V.Voronova, P. Glybochko, A. Svistunov, V. Fomin, P. Kopylov, P. Tzarkov, A. Egorov, E. Gitel, A. Ragimov, A. Boroda, E. Poddubskaya and M. Sekacheva. Diagnostic Value of Combinatorial Markers in Colorectal Carcinoma. Front. Oncol., 22 May 2020, volume 10. doi: 10.3389/fonc.2020.00832

Goltsov A, Sokolovski SG, Sidorov VV, Rafailov E. Editorial: Advanced non-invasive photonic methods for functional monitoring of haemodynamics and vasomotor regulation in health and diseases. Frontiers in Physiology. April 2020. V 11, Article 325. doi: 10.3389/fphys.2020.00325

M&S Decisions attended the ASCO 2020 Virtual Scientific Program, USA

Victor Sokolov, Tatiana Yakovleva, Lulu Chu, Weifeng Tang, Peter J. Greasley, Susanne Johansson, Kirill Peskov, Gabriel Helmlinger, David W. Boulton, Robert C. Penland. 2020. Differentiating the Sodium‐Glucose Cotransporter 1 Inhibition Capacity of Canagliflozin vs. Dapagliflozin and Empagliflozin Using Quantitative Systems Pharmacology Modeling, CPT Pharmacometrics Syst Pharmacol. 2020 Feb 16. doi: 10.1002/psp4.12498

A new article was published in Frontiers in Oncology journal

Voronova V, Sokolov V, Al-Khaifi A, Straniero S, Kumar C, Peskov K, Helmlinger G, Rudling M, Angelin B. A physiology-based model of bile acid distribution and metabolism under healthy and pathological conditions in humans. Cell Mol Gastroenterol Hepatol. Volume 10, Issue 1, 2020, Pages 149-170. doi: 10.1016/j.jcmgh.2020.02.005

Sokolov SS, Vorobeva MA, Smirnova AI, Smirnova EA, Trushina NI, Galkina KV, Severin FF and Knorre DA (2020) LAM Genes Contribute to Environmental Stress Tolerance but Sensibilize Yeast Cells to Azoles. Front. Microbiol. 11:38. doi: 10.3389/fmicb.2020.00038

Sofronova, A., Semenyuk, P., and Muronetz, V. (2019). The influence of β-casein glycation on its interaction with natural and synthetic polyelectrolytes. Food Hydrocoll. 89, 425–433. doi: 10.1016/j.foodhyd.2018.11.011

G. Helmlinger, V. Sokolov, K. Peskov, K.M. Hallow, Yu. Kosinsky, V. Voronova, L. Chu, T. Yakovleva, I. Azarov, D. Kaschek, A. Dolgun, H. Schmidt, D.W. Boulton, R.C. Penland. (2019) Quantitative Systems Pharmacology: An Exemplar Model Building Workflow with Applications in Cardiovascular, Metabolic and Oncology Drug Development, CPT: Pharmacometrics and Systems Pharmacology. doi: 10.1002/psp4.12426

Yuri Kosinsky, Denis Laryushkin, Kirill Peskov. DLBCL driver mutation profiles as predictors for gene expression signatures values in tumor biopsy: exploration by machine learning approaches. 4-7 November 2019, Heidelberg, Germany.

Victor Sokolov, Gabriel Helmlinger, Catarina Nilsson, Kirill Zhudenkov, Stanko Skrtic, Bengt Hamrén, Kirill Peskov, Eva Hurt-Camejo, and Rasmus Jansson-Löfmark. Comparative quantitative systems pharmacology modeling of anti-PCSK9 therapeutic modalities in hypercholesterolemia. J Lipid Res. 2019 Sep; 60(9): 1610–1621. doi: 10.1194/jlr.M092486

V. Voronova, Y. Kosinsky, S. Lebedeva, M. Sekacheva, G. Helmlinger, K. Peskov. Efficacy of combined radio- and immuno-therapies vs. radiotherapy alone in the treatment of brain metastases: a systematic review and meta-analysis. 2019 SITC, National Harbor, USA.

Comparison of the urinary glucose excretion contributions ofSGLT2 and SGLT1: A quantitative systems pharmacologyanalysis in healthy individuals and patients with type2 diabetes treated with SGLT2 inhibitors

Tatiana Yakovleva, Victor Sokolov, Lulu Chu, Weifeng Tang, Peter J. Greasley, Helena Peilot Sjögren, Susanne Johansson, Kirill Peskov, Gabriel Helmlinger, David W. Boulton, Robert C. Penland. Comparison of the urinary glucose excretion contributions of SGLT2 and SGLT1: A quantitative systems pharmacology analysis in healthy individuals and patients with type 2 diabetes treated with SGLT2 inhibitors. Diabetes Obes Metab. 2019 Aug 18. doi: 10.1111/dom.13858

V. Sokolov, A. Dolgun, K. Zhudenkov, G. Helmlinger, K. Peskov. Evaluation of MATLAB SimBiology functionality in comparison to other MATLAB and R-based software in the framework of quantitative systems pharmacology model development workflow. 2019 ACOP10 Conference, Orlando, USA.

Sergey Gavrilov, Kirill Zhudenkov, Kirill Peskov, Gabriel Helmlinger, Sergey Aksenov. Evaluation of longitudinal biomarkers associated with survival of prostate cancer patients by means of Bayesian joint modeling. StanCon, 2019, Conference, Cambridge, UK.

Comparative quantitative systems pharmacology modeling of anti-PCSK9 therapeutic modalities in hypercholesterolemia

Azarov, I., Peskov, K., Helmlinger, G., & Kosinsky, Y. (2019). Role of T Cell-To-Dendritic Cell Chemoattraction in T Cell Priming Initiation in the Lymph Node: An Agent-Based Modeling Study. Frontiers in Immunology, 10, 1289. doi: 10.3389/fimmu.2019.01289

B. Shulgin, Yu. Kosinsky, A. Smirnova, K. Peskov, Quantification of dose dependence of immune mediated adverse events of PD 1 and CTLA 4 inhibitors monotherapies and combinations using a Bayesian meta-analysis. StanCon, 2019, Conference, Cambridge, UK.

Busse D, Tang W, Scheerer MF, Danne T, Biester T, Sokolov V, Boulton DW and Parkinson J. Comparison of pharmacokinetics and the exposure-response relationship of dapagliflozin between adolescent/young adult and adult patients with type 1 diabetes mellitus. Br J Clin Pharmacol. 2019. Ms no. MP-00894-18.R2. doi: 10.1111/bcp.13981

Kirill Peskov, Ivan Azarov, Lulu Chu, Veronika Voronova, Yury Kosinsky, Gabriel Helmlinger. Quantitative mechanistic modelling in support of pharmacological therapeutics development in immuno-oncology. Front. Immunol. doi: 10.3389/fimmu.2019.00924

Kirill Zhudenkov, Robert Palmér, Alexandra Jauhiainen, Gabriel Helmlinger, Oleg Stepanov, Kirill Peskov, Ulf G Eriksson, Ulrika Wählby Hamrén. Longitudinal FEV1 and exacerbation risk in COPD: Quantifying the association using joint modelling. PAGE Meeting, 2019, Stockholm, Sweden.

Sokolov V, Yakovleva T, Ueda S, Parkinson J, Boulton D W, Penland R C, Tang W. Urinary glucose excretion after dapagliflozin treatment: An exposure-response modelling comparison between Japanese and non-Japanese patients diagnosed with type 1 diabetes mellitus. Diabetes Obes Metab. 2019; 21:829–836. doi: 10.1111/dom.13586 

Ivanenkov, Y.A., Zhavoronkov, A., Yamidanov, R.S., Osterman, I.A., Sergiev, P.V., Aladinskiy, V.A., Aladinskaya, A.V., Terentiev, V.A., Veselov, M.S., Ayginin, A.A., Kartsev, V.G., Skvortsov, D.A., Chemeris, A.V., Baimiev, A.Kh., Sofronova, A.A., Malyshev, A.S., et al. (2019). Identification of Novel Antibacterials Using Machine Learning Techniques. Front. Pharmacol. 10, 913. doi: 10.3389/fphar.2019.00913

Sergey Gavrilov, Kirill Zhudenkov, Kirill Peskov, Gabriel Helmlinger, Sergey Aksenov. Longitudinal assessment of tumor size and neutrophil count in multivariate joint models are more predictive of survival than their baseline values in patients with non-small cell lung cancer. PAGE Meeting, 2019, Stockholm, Sweden.

Kirill Zhudenkov, Robert Palmér, Alexandra Jauhiainen, Gabriel Helmlinger, Oleg Stepanov, Kirill Peskov, Ulf G Eriksson, Ulrika Wählby Hamrén. Longitudinal FEV1 and exacerbation risk in COPD: Quantifying the association using joint modelling. PAGE Meeting, 2019, Stockholm, Sweden.

BIOS consortium, GoNL consortium, Shvetsova, E., Sofronova, A., Monajemi, R., Gagalova, K., Draisma, H.H.M., White, S.J., Santen, G.W.E., Chuva de Sousa Lopes, S.M., et al. (2019). Skewed X-inactivation is common in the general female population. Eur. J. Hum. Genet. 27, 455–465. doi: 10.1038/s41431-018-0291-3

Ivanenkov, Y.A., Machulkin, A.E., Garanina, A.S., Skvortsov, D.A., Uspenskaya, A.A., Deyneka, E.V., Trofimenko, A.V., Beloglazkina, E.K., Zyk, N.V., Koteliansky, V.E., Bezrukov, D.S., Aladinskaya, A.V., Vorobyeva, N.S., Puchinina, M.M., Riabykh, G.K., Sofronova, A.A., Malyshev, A.S., Majouga, A.G. (2019). Synthesis and biological evaluation of Doxorubicin-containing conjugate targeting PSMA. Bioorg. Med. Chem. Lett. 29, 1246–1255. doi: 10.1016/j.bmcl.2019.01.040

Sergey Gavrilov, Kirill Zhudenkov, Kirill Peskov, Gabriel Helmlinger, Sergey Aksenov. Longitudinal tumor size and NLR are more predictive of individual survival than their baseline values in patients with non-small cell lung cancer treated with durvalumab. 2019 ASCO Annual Meeting, Chicago, USA.

Sergey Gavrilov, Kirill Zhudenkov, Kirill Peskov, Gabriel Helmlinger, Sergey Aksenov. Longitudinal assessment of tumor size and neutrophil count in multivariate joint models are more predictive of survival than their baseline values in patients with non-small cell lung cancer. PAGE Meeting, 2019, Stockholm, Sweden.

Veselov, M.S., Ivanenkov, Y.A., Yamidanov, R.S., Osterman, I.A., Sergiev, P.V., Aladinskiy, V.A., Aladinskaya, A.V., Terentiev, V.A., Ayginin, A.A., Skvortsov, D.A., Komarova, K.S., Chemeris, A.V., Baimiev, A.K., Sofronova, A.A., et al. (2019). Identification of pyrrolo-pyridine derivatives as novel class of antibacterials. Mol. Divers. doi: 10.1007/s11030-019-09946-3

Ivanenkov, Y.A., Yamidanov, R.S., Osterman, I.A., Sergiev, P.V., Aladinskiy, V.A., Aladinskaya, A.V., Terentiev, V.A., Veselov, M.S., Ayginin, A.A., Skvortsov, D.A., Sofronova, A.A., et al. (2019). Identification of N-Substituted Triazolo-azetidines as Novel Antibacterials using pDualrep2 HTS Platform. Comb. Chem. High Throughput Screen. 22, 346–354. doi: 10.2174/1386207322666190412165316

Pablo Morentin Gutierrez, Yuri Kosinsky, Kirill Peskov, Ivan Azarov, Lulu Chu, Veronika Voronova, Martin Johnson, Yingxue Chen, Larissa Carnevalli, Danielle Carroll, Michele Moschetta, Teresa Klinowska, Gabriel Helminger. Mechanistic insights and dose optimization for AZD3458, a novel selective PI3Kʏ immuno-modulator, using a quantitative systems approach. Annual Meeting of American Association of Cancer Research 2019, Atlanta, USA.

Sergey Gavrilov, Kirill Zhudenkov, Kirill Peskov, Gabriel Helmlinger, Sergey Aksenov. Longitudinal tumor size and NLR are more predictive of individual survival than their baseline values in patients with non-small cell lung cancer treated with durvalumab. 2019 ASCO Annual Meeting, Chicago, USA.

Ivanenkov, Y.A., Yamidanov, R.S., Osterman, I.A., Sergiev, P.V., Aladinskiy, V.A., Aladinskaya, A.V., Terentiev, V.A., Veselov, M.S., Ayginin, A.A., Skvortsov, D.A., Sofronova, A.A., et al. (2019). Large-scale high-throughput screening revealed 5’-(carbonylamino)-2,3’-bithiophene-4’-carboxylate as novel template for antibacterial agents. Curr. Drug Discov. Technol. 16. doi: 10.2174/1570163816666190603095521

Ivanenkov, Y.A., Komarova, E.S., Osterman, I.A., Sergiev, P.V., Yamidanov, R.S., Deineka, E.V., Terent’ev, V.A., Fil’kov, G.I., Sofronova, A.A., Mazhuga, A.G., et al. (2019). N-Pyridyl-Substituted Carboxypiperidine Amides: A New Class of Prokaryote Translation Inhibitors. Pharm. Chem. J. 53, 225–229. doi: 10.1007/s11094-019-01984-3

Ivan Azarov, Yury Kosinsky, Veronika Voronova, Lulu Chu, Suzanne I.S. Sitnikova, Simon Dovedi, Kirill Peskov, Gabriel Helminger. Linking tumor microenvironment properties in murine syngeneic tumors with resistance to immune checkpoint inhibitors: Insights from a quantitative systems approach. Annual Meeting of American Association of Cancer Research 2019, Atlanta, USA.

Ivanenkov, Y.A., Yamidanov, R.S., Osterman, I.A., Sergiev, P.V., Ayginin, A.A., Aladinskiy, V.A., Aladinskaya, A.V., Terentiev, V.A., Veselov, M.S., Skvortsov, D.A., Sofronova, A.A., et al. (2019). Substituted Furanocoumarins as Novel Class of Antibacterial Translation Inhibitors. Comb. Chem. High Throughput Screen. 22, 400–410. doi: 10.2174/1386207322666190723110539

Ivanenkov, Y.A., Yamidanov, R.S., Osterman, I.A., Sergiev, P.V., Aladinskiy, V.A., Aladinskaya, A.V., Terentiev, V.A., Veselov, M.S., Ayginin, A.A., Skvortsov, D.A., Sofronova, A.A., et al. (2019). 2-Pyrazol-1-yl-thiazole derivatives as novel highly potent antibacterials. J. Antibiot. (Tokyo). doi: 10.1038/s41429-019-0211-y 

Ivanenkov, Y.A., Osterman, I.A., Komarova, E.S., Bogdanov, A.A., Sergiev, P.V., Dontsova, O.A., Sofronova, A.A., Terentiev, V.A., Filkov, G.I., Yamidanov, R.S., et al. (2019). Tetrahydrocarbazoles as Novel Class of DNA Biosynthesis Inhibitors in Bacteria. Anti-Infect. Agents 17. doi: 10.2174/2211352517666181218155259 

Al‐Khaifi, S. Straniero V. Voronova, D. Chernikova, V. Sokolov, C. Kumar, B. Angelin, M. Rudling. Asynchronous rhythms of circulating conjugated and unconjugated bile acids in the modulation of human metabolism. Journal of Internal Medicine, 2018, 284; 546-559. doi: 10.1111/joim.12811

Veronika Voronova, Victor Sokolov, Dina Chernikova, Amani Al-Khaifi, Sara Straniero, Chanchal Kumar, Kirill Peskov, Gabriel Helmlinger, Mats Rudling, Bo Angelin. A physiology-based model of the distribution of individual bile acids within the enterohepatic circulation under normal and pathological conditions in human. XXV International Bile Acid Meeting: Bile Acids in Health and Disease 2018, Dublin, Ireland.

Snezhkina AV, Lukyanova EN, Kalinin DV, Pokrovsky AV, Dmitriev AA, Koroban NV, Pudova EA, Fedorova MS, Volchenko NN, Stepanov OA, Zhevelyuk EA, Kharitonov SL, Lipatova AV, Abramov IS, Golovyuk AV, Yegorov YE, Vishnyakova KS, Moskalev AA, Krasnov GS, Melnikova NV, Shcherbo DS, Kiseleva MV, Kaprin AD, Alekseev BY, Zaretsky AR, Kudryavtseva AV. Exome analysis of carotid body tumor. BMC Med Genomics (2018) Feb 13; 11(Suppl 1):17. 

Victor Sokolov, Tatiana Yakovleva, Shinya Ueda, Joanna Parkinson, Robert C. Penland, David W. Boulton, Weifeng Tang. Dapagliflozin Exposure–Response in Japanese vs Non-Japanese Patients with Type 1 Diabetes. 78th Scientific Sessions of American Diabetes Association, Orlando, USA.

Voronova V, Zhudenkov K, Penland RC, Boulton DW, Helmlinger G, Peskov K. Exenatide effects on gastric emptying rate and the glucose rate of appearance in plasma: A quantitative assessment using an integrative systems pharmacology model. Diabetes Obes Metab. 2018; 20:2034–2038. 

V Voronova, K Zhudenkov, R C. Penland, D W. Boulton, G Helmlinger, K Peskov. Exenatide effects on gastric emptying and oral glucose appearance in plasma: A quantitative assessment using an integrative systems pharmacology model. 9th American Conference on Pharmacometrics (ACoP9), San-Diego, USA.

Yu. Kosinsky, S. Dovedi, K. Peskov, V. Voronova, L. Chu, H. Tomkinson, N. Al-Huniti, D. Stanski, G. Helmlinger. (2018) Radiation and PD-(L)1 treatment combinations: immune response and dose optimization via a predictive systems model, Journal for ImmunoTherapy of Cancer (2018) 6:17. 

Victor Sokolov, Artem Dolgun, Kirill Zhudenkov, Henning Schmidt, Gabriel Helmlinger, Kirill Peskov. Evaluation of the utility of a MATLAB and R-based workflow for the development of quantitative systems pharmacology (QSP) models. 9th American Conference on Pharmacometrics (ACoP9), San-Diego, USA.

Petrov, R.A., Maklakova, S.Y., Ivanenkov, Y.A., Petrov, S.A., Sergeeva, O.V., Yamansarov, E.Y., Saltykova, I.V., Kireev, I.I., Alieva, I.B., Deyneka, E.V., Sofronova, A.A., et al. (2018). Synthesis and biological evaluation of novel mono- and bivalent ASGP-R-targeted drug-conjugates. Bioorg. Med. Chem. Lett. 28, 382–387. doi.org/10.1016/j.bmcl.2017.12.032.

Yuri Kosinsky, Ivan Azarov, Lulu Chu, Gabriel Helmlinger, Kirill Peskov, Sergey Aksenov. Comparison of different approaches to modeling early tumor size dynamics for accurate prediction of survival in non-small cell lung cancer (NSCLC) clinical trials. 9th American Conference on Pharmacometrics (ACoP9), San-Diego, USA.

Kirill Zhudenkov, Oleg Stepanov, Ulf Eriksson, Robert Palmér, Alexandra Jauhiainen, Kirill Peskov, Gabriel Helmlinger, Ulrika Wählby Hamrén. Quantification of lung function and risk of COPD exacerbation association to predict long-term effects for new treatment arms using a drug-differentiated joint model. 9th American Conference on Pharmacometrics (ACoP9), San-Diego, USA.

Veronika Voronova, Lulu Chu, Yuri Kosinsky, Alexandra Borodovsky, Richard Woessner, Kris Sachsenmeier, Ganesh Mugundu, Melinda Merchant, Wenlin Shao, Kirill Peskov, Gabriel Helmlinger. Anti-tumor synergy evaluation of an AZD4635/ anti-PD-L1 combination therapy using a quantitative systems model. The Society for Immunotherapy of Cancer Annual Meeting, Washington D.C., USA.

Yuri Kosinsky, Simon Dovedi, Kirill Peskov, Veronika Voronova, Lulu Chu, Don Stanski, Gabriel Helmlinger. Immune cell responses and dose scheduling optimization of radiation and anti-PD-L1 treatment combination using a joint experimental and systems modeling approach. The Society for Immunotherapy of Cancer Annual Meeting, Washington D.C., USA.

Boris Shulgin, Yuri Kosinsky, Andrey Omelchenko, Lulu Chu, Ganesh Mugundu, Garrett DeYulia, Rodrigo Pimentel, Kirill Peskov, Gabriel Helmlinger. Characterizing immune-mediated adverse events of anti-PD-1 and anti-CTLA-4 monotherapies and combinations using a quantitative model based meta-analysis. The Society for Immunotherapy of Cancer Annual Meeting, Washington D.C., USA.

Victor Sokolov, Eva Hurt-Camejo, Catarina Nilsson, Kirill Zhudenkov, Stanko Skrtic, Bengt Hamrén, Kirill Peskov, Gabriel Helmlinger, Rasmus Jansson-Löfmark (2018) Differentiation of anti-PCSK9 antibodies and synthesis inhibitors: a drug-disease modeling study. ASCPT 2018 Annual Meeting, Orlando, FL, USA.

Tatiana Yakovleva, Victor Sokolov, Lulu Chu, Robert C. Penland, Weifeng Tang, Peter J. Greasley, Susanne Johansson, Kirill Peskov, Gabriel Helmlinger, David W. Boulton (2018) Contribution and regulation of SGLT1 and SGLT2 in healthy and type 2 diabetes subjects: a drug-disease modeling study. ASCPT 2018 Annual Meeting, Orlando, FL, USA.

Artem Dolgun, Victor Sokolov, Henning Schmidt, Nidal Al-Huniti, Gabriel Helmlinger, Kirill Peskov (2018) A functional, integrative R environment workflow for the development and use of quantitative systems pharmacology models. PAGE 2018 Conference, Montreux, Switzerland.

Radiation and PD-(L)1 treatment combinations: immune response and dose optimization via a predictive systems model

Veronika Voronova, Victor Sokolov, Dina Chernikova, Amani Al-Khaifi, Sara Straniero, Chanchal Kumar, Kirill Peskov, Gabriel Helmlinger, Mats Rudling, Bo Angelin (2018) Using a physiologically-based QSP model to simulate the effects of enterohepatic circulation perturbations on the distribution of bile acids. PAGE 2018 Conference, Montreux, Switzerland.

Kosinsky Yu, Chu L, Peskov K, Voronova V, Borodovsky A, Woessner R, Sachsenmeier K, Al-Huniti N, Helmlinger G. (2018) Quantitative modeling as a systematic approach for drug combination evaluation in Immuno-Oncology. AACR 2018 annual meeting, Chicago, USA.

Helmlinger, G., Al-Huniti, N., Aksenov, S., Peskov, K., Hallow, K. M., Chu, L., Boulton, D., Eriksson, U., Hamrén, B., Lambert, C., Masson, E., Tomkinson, H., & Stanski, D. (2017) Drug-disease modeling in the pharmaceutical industry – where mechanistic systems pharmacology and statistical pharmacometrics meet. European Journal of Pharmaceutical Sciences, Volume 109 (S), Pages S39-S46. 

Kosinsky, Y., Dovedi, S., Peskov, K., Voronova, V., Chu, L., Tomkinson, H., Al-Huniti, N., Stanski, D., & Helmlinger, G. (2017) Radiation and anti-PD-L1 treatment combinations: Immune cell responses and dose scheduling optimization using a joint experimental and systems modeling approach. PKUK 2017 Meeting, Great Malvern, UK.

Panov, A., Kochkina, J., Yartsev, E., Eremin, D., Yakovleva, T., & Kedik, S. (2017) Modification of the antitumor effect of cytotoxic drugs by copolymers of N-vinylpyrrolidone and 2-methyl-5-vinylpyridine. Pharmaceutical Chemistry Journal, 51(7), 3—7.

Abdallah, K., Shulgin, B., Peskov, K., Kosinsky, Y., Vergara-Silva, A., Helmlinger, G., Chu, L., & Masson, G. (2017) Model-based meta-analysis of safety for immune checkpoint inhibitor combinations and monotherapy, ASCO-SITC Clinical Immuno-Oncology Symposium, Orlando, USA.

Tsurikov, S. M., Goncharov, A. A. & Tiunov, A. V. (2015) Intrabody variation and ontogenetic changes in the isotopic composition (13C/12C and 15N/14N). Zoologicheskii Zhurnal, 94(3), 336 – 344.

Voronova, V., Zhudenkov, K.,  Helmlinger, G., & Peskov, K. (2017). Interpretation of metabolic memory phenomenon using a physiological systems model: What drives oxidative stress following glucose normalization? PLoS ONE,12(2), e0171781. 

Kosinsky, Y., Dovedi, S., Peskov, K., Voronova, V., Chu, L., Masson, E., Tomkinson, H., Al-Huniti, N., Stanski, D., & Helmlinger, G. (2017) Radiation and anti-PD-L1 treatment combinations: Immune cell responses and dose scheduling optimization using a joint experimental and systems modeling approach. Abstracts of the Annual Meeting of the Population Approach Group in Europe (PAGE), Budapest, Hungary, ISSN 1871-6032.

Zhikrivetskaya, S. O., Snezhkina, A. V., Zaretsky, A. R., Alekseev, B. Y., Pokrovsky, A. V., Golovyuk, A. L., Melnikova, N. V.,  Stepanov, O. A., Kalinin, D. V., Moskalev, A. A., Krasnov, G. S., Dmitriev, A. A., & Kudryavtseva, A. V. (2017). Molecular markers of paragangliomas/pheochromocytomas. Oncotarget, 8, 25756. 

Chernikova, D., Sokolov, V., Voronova, V., Al-Khaifi, A., Straniero, S., Rudling, M., Kumar, C., Peskov, K., Helmlinger, G., & Angelin, B. (2017) Inhibition of bile acids synthesis via fibroblast growth factor 19 (FGF19) through intestinal signaling: A population analysis. Abstracts of the Annual Meeting of the Population Approach Group in Europe (PAGE), Budapest, Hungary, ISSN 1871-6032. 

Potapov, A. M., Goncharov, A. A., Semenina, E. E., Korotkevich, A. Yu., Tsurikov, S. M., Rozanova, O. L., Anichkin, A. E., Zuev, A. G., Samoylova, E. S., Semenyuk, I. I., Yevdokimov, I. V., & Tiunov, A. V. (2017) Arthropods in the subsoil: Abundance and vertical distribution as related to soil organic matter, microbial biomass. European Journal of Soil Biology, 82, 88—97.

Onishchenko, D., Dunyak, J., Helmlinger, G., Masson, E., Tomkinson, H., Peskov, K., & Al-Huniti, N. (2017) Joint modeling of overall survival and tumor size dynamics in non-small cell lung cancer: Clinical trial simulations and validation of predictions at study and subject levels. Abstracts of the Annual Meeting of the Population Approach Group in Europe (PAGE), Budapest, Hungary, ISSN 1871-6032. 

Ryskov, A. P., Osipov, F. A., Omelchenko, A. V., Semyenova, S. K., Girnyk, A. E., Korchagin, V. I., Vergun, A. A., & Murphy, R. W. (2017) The origin of multiple clones in D. rostombekowi. PLoS ONE, 12(9), e018516.

Voronova, V., Zhudenkov, K., Penland, R. C., Boulton, D. W., Helmlinger, G., & Peskov, K. (2017) Evaluation of immediate release exenatide effects on gastric motility and intestinal glucose absorption using a systems pharmacology model. Abstracts of the Annual Meeting of the Population Approach Group in Europe (PAGE), Budapest, Hungary, ISSN 1871-6032.

Chernikova, D., Pázsit, I., Favalli, A., & Croft, S. (2017) The Inclusion of Photofission, Photonuclear, (n, xn), (n, n′xγ), and (n, xγ) Reactions in the Neutron-Gamma Feynman-Alpha Variance-to-Mean Formalism. Nuclear Science and Engineering, 185, 206—216.

Kosinsky, Y., Peskov, K, Voronova, V, Chu, L., Al-Huniti, N., Masson, E., & Helmlinger, G. (2017) Quantitative Systems Pharmacology (QSP) modeling as a systematic approach for drug combination evaluation in Immuno-Oncology (IO). 8th American Conference on Pharmacometrics (ACoP8), Fort Lauderdale, USA.

Girnyk, A. E., Vergun, A. A., Omelchenko, A. V., Petrosyan, V. G., Korchagin, V. I., & Ryskov, A. P. (2017) Molecular and genetic characterization of the allelic variants of Du215, Du281, Du323, and Du47G microsatellite loci in D. armeniaca. Russian Journal of Genetics, 53(4), 472–482.

Sokolov, V., Chu, L., Kosinski, Y., Al-Huniti, N., Fox, R., Schmidt, H., Onishchenko, D., Voronova, , Zhudenkov, K., Helmlinger, G., & Peskov, K. (2017) Drug-Disease modeling: a practical workflow from model development to simulations. 8th American Conference on Pharmacometrics (ACoP8), Fort Lauderdale, USA.

Sofronova, A.A., Evstafyeva, D.B., Izumrudov, V.A., Muronetz, V.I., and Semenyuk, P.I. (2017). Protein-polyelectrolyte complexes: Molecular dynamics simulations and experimental study. Polymer 113, 39–45. doi.org/10.1016/j.polymer.2017.02.047. 

Sokolov, V., Goncharov, A., Hurt-Camejo, E., Nilsson, C., Zhudenkov, K., Skrtic, S., Hamrén, B., Peskov, K., Helmlinger, G., Jansson-Löfmark, R. (2017) Differentiation of anti-PCSK9 antibodies and synthesis inhibitors using Drug-Disease modeling of lipoprotein metabolism. 8th American Conference on Pharmacometrics (ACoP8), Fort Lauderdale, USA.

Sofronova, A.A., Izumrudov, V.A., Muronetz, V.I., and Semenyuk, P.I. (2017). Similarly charged polyelectrolyte can be the most efficient suppressor of the protein aggregation. Polymer 108, 281–287. doi.org/10.1016/j.polymer.2016.11.073. 

Yakovleva, T., Sokolov, V., Chu, L., Penland, R. C., Tang, W., Greasley, P. J., Johansson, S., Peskov, K., Helmlinger, G., & Boulton, D. W. (2017) Drug-disease modeling of renal glucose reabsorption in healthy and diabetes subjects: Investigating differences in SGLT2 inhibitors pharmacodynamics. 8th American Conference on Pharmacometrics (ACoP8), Fort Lauderdale, USA.

Zhudenkov, K., Chernikova, D., Onishchenko, D., Al-Huniti, N., Peskov, K., Helmlinger, G., Eriksson, U., Palmer, R., & Jauhiainen, A. (2017) Dynamic prediction of treatment response and probability of exacerbation in COPD using joint modeling. 8th American Conference on Pharmacometrics (ACoP8), Fort Lauderdale, USA.

Al-Huniti, N., Onishchenko, D., Xu, H., Zhou, D., Masson, E., Helmlinger, G., Tomkinson, H., Abdallah, & K., Dunyak, J. (2017) Dynamic prediction of pregression free survival (PFS) and overall survival (OS) in non-small cell lung cancer (NSCLC) using tumor size: A longitudinal joint modeling approach. ASCPT meeting, Washington D.C., USA.

Sokolov, V., Hurt-Camejo, E., Nilsson, C., Zhudenkov, K., Skrtic, S., Hamren, B., Peskov, K., Helmlinger, G., & Jansson-Lofmark, R. (2017) Properties of Anti-PCSK9 Antibodies and Synthesis Inhibitors Using a Quantitative Systems Model of Lipoprotein Metabolism. American Diabetic Association (ADA) scientific sessions, San Diego, California.

Voronova, V., Sokolov, V., Al-Khaifi, A., Straniero, S., Rudling, M., Chanchal, K., Peskov, K., Helmlinger, G., & Angelin, B. (2017) Systems Pharmacology Modeling of Bile Acid Distribution and Signaling in Humans. Keystone symposia: Bile Acid Receptors as Signal Integrators in Liver and Metabolism, Monterey, USA.

Domijan, M., Brown, P.E., Shulgin, B. V., & Rand, D. A. (2016). PeTTSy: a computational tool for perturbation analysis of complex systems biology models. BMC bioinformatics, 17(1), 124. 

Kosinsky, K., Peskov, K., Shulgin, B., Stepanov, O., Voronova, V., Masson, E., & Helmlinger, G. (2016) Investigation of anti-CTLA-4 immuno-oncology therapy through a quantitative systems pharmacology model. Abstracts of the Annual Meeting of the Population Approach Group in Europe (PAGE), Lisbon, Portugal.

Karelina, T., Voronova, V., Demin, O., Colice, G., & Agoram, B. M. (2016). A Mathematical Modelling Approach to Understanding the Effect of Anti-Interleukin Therapy on Eosinophils. CPT Pharmacometrics Syst. Pharmacol, 5(11), 608. 

Sokolov, S., Yakovleva, T., Zhudenkov, K., Mercier, A-K., Helmlinger, G., Peskov, K., & Eriksson, U. (2016) A mechanistic PKPD model relating early asthmatic response to anti-leukotriene drug PK and biomarker levels in allergen challenge studies. Abstracts of the Annual Meeting of the Population Approach Group in Europe (PAGE), Lisbon, Portugal. 

Shulgin, B., Helmlinger, G., & Kosinsky, Yu. (2016). A Generic Mechanism for Enhanced Cytokine Signaling via Cytokine-Neutralizing Antibodies. PLoS One, 11(2), e0149154. 

Stepanov, O., Voronova, V., Kosinsky, Y., Peskov, K., Masson, E., & Helmlinger, G. (2016) A quantitative systems pharmacology model to explore combination efficacy of immuno-oncology compounds: Effects of CXCR2 and PD-1 inhibitions. Abstracts of the Annual Meeting of the Population Approach Group in Europe (PAGE), Lisbon, Portugal. 

Shashkova, T., Popenko A., Tyakht A., Peskov K., Kosinsky Y., Bogolubsky L., Raigorodskii A., Ischenko D., Alexeev D., & Govorun V. (2016). Agent Based Modeling of Human Gut Microbiome Interactions and Perturbations. PLoS One, 11(2), e0148386.

Voronova, V., & Zhudenkov, K. (2016) Investigation of the diabetes-related metabolic memory phenomenon using a quantitative systems pharmacology approach. Abstracts of the Annual Meeting of the Population Approach Group in Europe (PAGE), Lisbon, Portugal.

Rozova, S., & Bratus, A. S. (2016). Therapy strategy in tumour cells and immune system interaction mathematical model. Applicable Analysis, 95, 1548–1559. 

Yakovleva, T., Sokolov, V., & Zhudenkov, K. (2016) A systems pharmacology model of SGLT2 and SGLT1 inhibition to understand mechanism and quantification of urinary glucose excretion after treatment with Dapagliflozin, Canagliflozin and Empagliflozin. Abstracts of the Annual Meeting of the Population Approach Group in Europe (PAGE), Lisbon, Portugal. 

Snezhkina, A. V., Krasnov, G. S., Lipatova, A. V., Sadritdinova, A. F., Kardymon, O. L., Fedorova, M. S., Melnikova, N. V., Stepanov, A., Zaretsky, A. R., Kaprin, A. D., Alekseev, B. Y., Dmitriev, A. A., & Kudryavtseva, A.V. (2016). The Dysregulation of Polyamine Metabolism in Colorectal Cancer Is Associated with Overexpression of c-Myc and C/EBPβ rather than Enterotoxigenic Bacteroides fragilis Infection. OMCL, 2353560. 

Kosinsky, Y., Peskov, K., Shulgin, B., Stepanov, O., Voronova, V., Masson, E., & Helmlinger, G. (2016) Quantitative Systems Pharmacology model for immuno-oncology drug development: example of CTLA4 inhibition mechanism. International Conference on Systems Biology (ICSB), Barcelona, Spain.

Neroev V., Malyugin, B. E., Trubilin, V. N., Zhudenkov, V., & Orlova, O. M. (2016). Clinical and social burden of cataract in Russia. Cataract and Refractive Surgery, 16(1), 4–14.

Peskov, K., Stepanov, O., Voronova, V., Kosinsky, Y., Masson, E., & Helmlinger, G. (2016) A quantitative systems pharmacology model to explore combination efficacy of immuno-oncology compounds: Effects of CXCR2 and PD-1 inhibitions. International Conference on Systems Biology (ICSB), Barcelona, Spain.

Noren, D. P., Long, B. L., Norel, R., Rrhissorrakrai, K., Hess, K., Hu, C. W., Bisberg, A. J., Schultz, A., Engquist, E., Liu, L., Lin, X., Chen, G. M., Xie, H., Hunter, G. A. M., Boutros, P. C., Stepanov, , DREAM 9 AML-OPC Consortium, Norman, T., Friend, S. H., Stolovitzky, G., Kornblau, S., & Qutub, A.A. (2016) A Crowdsourcing Approach to Developing and Assessing Prediction Algorithms for AML (Acute Myeloid Leukemia) Prognosis. PLOS Computational Biology, 1004890. 

Shulgin, B., Helmlinger, G., & Kosinsky, Y. (2016) Enchancement of cytokine signaling via cytokine-neutralizing antibodies, International Conference on Systems Biology (ICSB), Barcelona, Spain.

Omelchenko, A. V., Girnyk, А. Е., Osipov, А., Petrosyan, V. G., Vergun, А. А., & Ryskov, А. P. (2016) Detection of genotypic changes in D. armeniaca. Russian Journal of Biological Invasions, 7(3), 275–282.

Girnyk, A., Omelchenko, A., Vergun, A., & Ryskov A. (2016) Genetic and clonal variation in the D. armeniaca. Book of Abstracts of 9th Symposium on the Lacertids of the Mediterranean Basin & 1st Symposium, Lemesos (Limassol), Cyprus, 55.

Omelchenko, A. V., Girnyk, A. E., Osipov, F. A., Vergun, A. A., Petrosyan, V. G., Danielyan, F. D., Arakelyan, M. S., & Ryskov, A. P. (2016) Genetic Differentiation among Natural Populations of the D. raddei as Inferred from Genome Microsatellite Marking. Russian Journal of Genetics, 52(2), 231–235.

Dolgun, A., & Myslivets, A. (2016) Universal SAS® macro for generating Statistical Analysis Report in one click for I-IV phase Clinical Trials. Annual Conference of the International Society for Clinical Biostatistics (ISCB), Birmingham, UK

Polovnikov, P. V., Azarov, I. B., & Veshchunov, M. S. (2016). Advancement of the kinetic approach to Brownian coagulation on the base of the Langevin theory. Journal of Aerosol Science, 96, 14-23.

Vinogradova, S. V., Zhudenkov, K. V., Benson, N., Van Der Graaf, P. H., Demin, O.V., & Karelina, T. A. (2015) Prediction of long-term treatment outcome in HCV following 24 day PEG-IFN alpha-2b therapy using population pharmacokinetic-pharmacodynamic mixture modeling and classification analysis. J Theor Biol., 8, 382, 91–98. 

Voronova, V., Karelina, T., Demin, O., & Chen, D. (2015) Understanding of GFR (Glomerular Filtration Rate) Changes in Response to ARB Administration using a Quantitative Systems Pharmacology Approach. ASCPT meeting, Indianapolis, USA.

Goncharov, A. A., Zalewski, M., Dudek, D., Godeau, J. F., Sienkiewicz, P., Ulrich, W., & Tiunov, A. V. (2015) Sex-related variation in δ15N. Pedobiologia, 58, 147–151.

Yakovleva, T., Demin, O. Jr., & Demin, O. (2015) Evaluation of minimum threshold hepatitis C virus concentration in plasma required for disease development. The 12th congress of EACPT.

Yakovleva, T., Demin, O. Jr., & Demin, O. (2015) The systems pharmacology model of hepatitis C progression and treatment. ASCPT meeting, Indianapolis, USA.

Veshchunov, M. S., & Azarov, I. B. (2015). Condensation rate of light vapour molecules in the transition regime. Journal of Aerosol Science, 86, 13—23.

Yakovleva, T., Demin, O. Jr., & Demin, O. (2015) The systems pharmacology model of hepatitis C progression: evaluation of minimal viral concentration required for disease development. The 15th International Symposium on Viral Hepatitis and Liver Disease (ISVHLD).

Demin, O. Jr, Yakovleva, T., Kolobkov, D., & Demin, O. (2014) Analysis of the efficacy of SGLT2 inhibitors using semi-mechanistic model. Front Pharmacol, 5, 218, 1–10. 

Caputo, A., &Peskov, K. (2014) Modeling Alzheimer’s Disease Progression Using the CDR Sum of Boxes Data from ADNI and in-house clinical data. Novartis Biostatistics conference, Basel, Switzerland.

Smirnov, S., Metelkin, E., Gizzatkulov, N., Stepanov, O., & Demin, O. (2014) Towards Modeling of Metabolic Syndrome: Tissue Crosstalk in Lipid Spillover. In M. Oresic, A. Vidal-Puig (Eds.) “A Systems Biology Approach to Study Metabolic Syndrome”. Springer, 341—366.

Dua, P., Demin, O. Jr., Sokolov, V., Yakovleva, T., Demin, O., & Van der Graaf, P. (2014) A systems pharmacology model of purine metabolism to explore novel options for the treatment of Gout. Systems Pharmacology in Drug Discovery & Development, Noordwijkerhout, Netherlands.

Sadritdinova, A. F., Dmitriev, A. A., Snezhkina, A. V., Belenikin, M. S., Krasnov, G. S., Manylov, O. G., Kudryavtsev, A. A., Melnikova, N. V., Speranskaya, A. S., Darii, M. V., Lakunina, V.A., Uroshlev, L. A., Smurov, A. O., Stepanov O. A., & Kudryavtseva, A.V. (2014) A new reliable reference gene UBA52 for quantitative real-time polymerase chain reaction studies in pyloric cecal tissues. Genetics and Molecular Research, 13(2), 3972–3980. 

Voronova, V., Demin, O. Jr., Smirnov, S., & Demin, O. (2014) Development and Application of Systems Pharmacology Model to Predict Nausea Resulted from Administration of GLP-1 Analogues. ASCPT meeting, Indianapolis, USA.

Vergun, A. A, Martirosyan, I. A., Semyenova, S. K., Omelchenko, A. V., Petrosyan, V. G., et al. (2014) Clonal Diversity and Clone Formation in D. dahli. PLoS ONE 9(3), e91674. doi:10.1371/journal.pone.0091674

Yakovleva, T., Demin, O. Jr., & Demin, O. (2014) Investigation of Dapagliflozin inhibition effect on glucose reabsorption using systems pharmacology approach. ASCPT Annual Meeting.

Azarov, I. B. & Veshchunov, M. S. (2014) On the Theory of Point Defect Recombination in Crystals. Journal of Experimental and Theoretical Physics, 119(3), 473–478.

Peskov, K.V. (2013) Mathematical modeling in drug development. Vestnik Roszdravnadzora (Bulletin of Federal Service on Surveillance in Healthcare), 1, 57–60.

Chen, D., Voronova, V., Smirnov, S., Goryacheva, E., Bakhmutova, A., & Demin, O. (2013) Development of Human System Pharmacology model to Characterize Diabetic Nephropathy Disease Progression and the Effect of Standard of Care Therapy. ACoP meeting, Fort Lauderdale, USA.

Demin, O. O., Smirnov, S. V., Sokolov, V. V., Cucurull-Sanchez, L., Pichardo-Almarza, C., Flores, M. V., Benson, N., & Demin, O. V. (2013) Modeling of celiac disease immune response and the therapeutic effect of potential drugs. BMC System Biology, 7, 56, 1–10.

Kosinsky, Y., Peskov, K., Popenko, A., Tyakht, A., & Alexeev, D. (2013) Modeling of short-chain fatty acids metabolism in human gut: reconstruction of possible relations between microbiota composition and type 2 diabetes status. International Conference on Systems Biology (ICSB), Copenhagen, Denmark.

Oparina, N. Yu., Snezhkina, A. V., Sadritdinova, A. F., Veselovskii, V. A., Dmitriev, A. A., Senchenko, V. N., Mel’nikova, N. V., Speranskaya, A. S., Darii, M. V., Stepanov, O., Barkhatov, I. M., & Kudryavtseva, A. V. (2013) Differential expression of genes that encode glycolysis enzymes in kidney and lung cancer in humans. Russian Journal of Genetics, 49(7), 707—716. 

Shulgin B., Ebling B., Machacek M., Data integration and PKPD modeling to support differentiation of a novel IL-10 Fc compound against hrIL-10, Science and Innovation Day, Novartis, Basel, 2013

Sadritdinova, A. F., Snezhkina, A. V., Dmitriev, A. A., Krasnov, G. S., Astakhova, L. N., Kudryavtsev, A. A., Mel’nikova, N. V., Speranskaya, A. S., Darii, M. V., Lakunina, V. A., Uroshlev, L. A., Smurov, A. O., Stepanov, O. A., & Kudryavtseva, A. V. (2013) A new reference gene, Ef1A, for quantitative real-time PCR assay of the starfish Asterias rubens pyloric ceca. Dokl Biol Sci., 452, 310-2. 

Omelchenko, A. V. (2013) Molecular characteristic of dinucleotide microsatellite loci of genome of D. unisexualis. Moscow. “Prometey” MSPU PRESS.

McIntosh, J. R., O’Toole, E., Zhudenkov, K., Morphew, M., Schwartz, C., Ataullakhanov, F. I., & Grishchuk, E. L. (2013) Conserved and divergent features of kinetochores and spindle microtubule ends from five species. J Cell Biol, 200(4), 459–74.

Karelina, T. A., Zhudenkov, K. V., Demin, O. O., Svetlichny, D. V., Agoram, B., Fairman, D., & Demin, O. V. (2012) Regulation of leukotriene and 5oxoETE synthesis and the effect of 5-lipoxygenase inhibitors: a mathematical modeling approach. BMC System Biology, 6 (141), 1—14.

Peskov, K., Kosinsky, Yu., Popenko, A., Tyakht, A., & Alexeev, D. (2012) Mechanistic modeling approach relating human gut microbial community to physiologically-relevant biomarkers. Population Approach Group Europe meeting (PAGE), Venice, Italy. 

Peskov, K., Mogilevskaya, E., & Demin, O. (2012) Kinetic modelling of central carbon metabolism in Escherichia coli. FEBS Journal, 279, 3374–3385. 

Zhudenkov, K., Helmlinger, G., & Schmidt, H. (2012) Application of the SBTOOLBOX2 in drug discovery and development. Population Approach Group Europe meeting (PAGE), Venice, Italy. 

Ostapchenko, V. G., Gasparian, M. E., Kosinsky, Yu. A., Efremov, R. G., Dolgikh, D. A., & Kirpichnikov, M. P. (2012) Dissecting structural basis of the unique substrate selectivity of human enteropeptidase catalytic subunit. Biomol. Struct. & Dyn, 30(1), 62–73. 

Karelina, T., Kazimirova, E., Zhudenkov, K., Demin, O. Jr, Lu, Y., Nicholas, T., Duvvuri, S., & Barton, H. A. (2012) Kinetic Model of Amyloid Beta Distribution and Allometric Scaling from Mouse to Monkey and Human. Population Approach Group Europe meeting (PAGE), Venice, Italy.

Petrosyan, V. G., Bessonov, S. A., & Omelchenko, A. V. (2012) Mathematical modeling of population dynamics and the demographic parameters for populations of moose (Alces alces) on the basis of long-term monitoring data. In E.V. Budilova (Ed.), “Mathematics and Reality: the Confrontation of Rigor and Complexity” (pp. 458-472). Moscow, M: Edition «Soliton».

Nicholas, T., Barton, B., Lu, Y., Duvvuri, S., Karelina, T., Demin, O.,  Zhudenkov, K., Belykh, S., Demin, & O. Jr. (2012) Beta-amyloid aggregation human systems pharmacology modeling: Development and application to pharmacological targets in Alzheimer’s disease. Alzheimer’s Association International Conference.

Petrosyan, V. G, Dergunova, N. N., Bessonov, S. A., & Omelchenko, A. V. (2012) Modeling the Dynamics of Population, Evaluation and Comparative Analysis of the Demographic Parameters of Moose in Russia and Finland Using Long-Term Monitoring Data. Mathematical Biology and Bioinformatics. 7(1), 244–256.

Veshchunov, M. S., & Azarov, I. B. (2012) Next approximation of the random walk theory for Brownian coagulation. Journal of Aerosol Science, 47, 70–77.

Zhudenkov, K., Vinogradova, S., & Karelina, T. (2011) Pharmacokinetics of PEG-IFN Alpha in HCV Infected Patients. Abstracts of the Annual Meeting of the Population Approach Group in Europe (PAGE).  

Peskov, K., Demidenko, A., Dorodnov, A., Demin, O., & Agoram, B. (2011) A Quantitative Systems Pharmacology Model Provides Insights into Phosphate Homoeostasis through Multiple Interacting Pathways. Population Approach Group Europe meeting (PAGE), Athens, Greece.

Peskov, K., Demidenko, A., Dorodnov, A., Demin, O., Nowlin, D., Kraynov, E., & Luu, K. (2011) System Modeling of EphB4/ephrinB2 Signaling Pathways. Population Approach Group Europe meeting (PAGE), Athens, Greece. 

Demidenko, A.,Peskov, K., Dorodnov, A., Demin, O., Nowlin, D., Kraynov, E., & Luu, K. (2011) System Modeling of EphB4/ephrinB2 Signaling Pathways. International Conference on Systems Biology (ICSB), Heidelberg/Mannheim, Germany

Svetlichny, D., Peskov, K., Demidenko, A., Demin, O., Kraynov, E., & Spilker, M. (2011) Systems modeling of integrin avb3 signaling pathway. International Conference on Systems Biology (ICSB), Heidelberg/Mannheim, Germany.

Omelchenko, A. V., Vergun, A. A., Petrosyan, V. G., & Tokarskaya, O. N. (2011) Models of molecular genetic structures of populations of D. unisexualis on the basis of molecular marking of the genomes. Proceedings of the International conference “Biological diversity and conservation problems”, Yerevan, Armenia, 224 — 227.

Gizzatkulov, N. M., Goryanin, I. I., Metelkin, E. A., Mogilevskaya, E. A., Peskov, K. V., & Demin, O. V. (2010) DBSolve Optimum: a software package for kinetic modeling which allows dynamic visualization of simulation results. BMC Systems Biology, 4, 109. doi: 10.1186/1752-0509-4-109

Karelina, T., Demin, O., Zhudenkov, K., Svetlichny, D., Demin, O. Jr., Fairman, D., & Agoram, B. (2010) Can systems modeling approach be used to understand complex PK-PD relationships? A case study of 5-lipoxygenase inhibition by zileuton. Abstracts of the Annual Meeting of the Population Approach Group in Europe (PAGE).

Azarov, I. B. & Veshchunov, M. S. (2010). Development of the new approach to the Brownian coagulation theory: transition regime. Journal of Engineering Thermophysics, 19(3), 128—137. doi: 10.1134/S1810232810030033

Pedentchouk, N., Peskov, K., Borland, A., Cartlidge, L., & Wagner, T. (2010) What causes Differences in 13C/12C and D/H Composition of n-Alkanes from Leaf Waxes among Higher Terrestrial Plants? Stable Isotopes and Biogeochemical Cycles in Terrestrial Ecosystems Conference, Ascona, Switzerland.

Mogilevskaya, E., Peskov, K., Metelkin, E., Plyusnina, T., Lebedeva, G., Goryanin, I., & Demin, O. (2009) Kinetic modeling of E. coli enzymes: integration of in vitro data. In S. Y. Lee (Ed.) “Systems Biology and Biotechnology of Esherichia coli”. Springer, 177 – 207. 

Goltsov, A., Maryashkin, A., Swat, M., Kosinsky, Y., Humphery-Smith, I., Demin, O., Goryanin I., & Lebedeva G. (2009) Kinetic modelling of NSAID action on COX-1: focus on in vitro/in vivoaspects and drug combinations. J. Pharmac. Sciences, 36, 122—136. 

Lesovoy, D. M., Bocharov, E. V., Lyukmanova, E. N., Kosinsky, Yu. A., Shulepko, M. A., Dolgikh, D. A., Kirpichnikov, M. P., Efremov, R. G., & Arseniev, A. S. (2009) Specific membrane binding of neurotoxin II can facilitate its delivery to acetylcholine receptor. J., 97(7), 2089–2097. 

Mogilevskaya, E., Bagrova, N., Plyusnina, T., Gizzatkulov, N., Metelkin, E., Goryacheva, E., Smirnov, S., Kosinsky, Y., Dorodnov, A., Peskov, K., Karelina, T., Lebedeva, G., Goryanin, I., & Demin O. (2009) Kinetic modeling as a tool to integrate multilevel dynamic experimental data. Methods Mol Biol, 563, 197 – 218. 

Omelchenko, A. V., & Korchagin, V. I. (2009) Thermodynamic characteristization of di-, tri, and tetranucleotide microsatellite loci in D. unisexualis. Russian Journal of Genetics, 45(8), 1004 – 1008.

Petrosyan, V. G., Dergunova, N. N., Bessonov, S. A., Nazarova, K. A., & Omelchenko, A. V. (2009) Estimation of population dynamics and population’s age-sex structure of a moose ( alces L.) in Russia by means simulation model and the data of multi-years monitoring. Journal of Samara Science Centre of the Russian Academy of Sciences, 11(7), 1566–1574.

Omelchenko, A. V., Korchagin, V. I., Sevast’yanova, G. A., Ryskov, A. P., Tokarskaya, O. N. (2009) Molecular genetic characteristic of dinucleotide microsatellite loci in D. unisexualis. Russian Journal of Genetics. 45(2), 203 – 210.