27/02/2018
New article on immuno-oncology QSP modeling was just published in the Journal of ImmunoTherapy of Cancer.
A mathematical model is presented. It integrates key mechanistic features of immuno-oncology biology, radiation and anti PD-L1 pharmacokinetics, to accurately predict optimal radiation and anti PD-L1 dose sequencing for maximal anti-tumor efficacy. Owing to its mechanistic nature, the model features mechanistic insights into the immune-suppressive vs. immuno-activating forces underlying drug regimen optimization.
