A new article was published in The Journal of Lipid Research

Victor Sokolov, Gabriel Helmlinger, Catarina Nilsson, Kirill Zhudenkov, Stanko Skrtic, Bengt Hamrén, Kirill Peskov, Eva Hurt-Camejo, and Rasmus Jansson-Löfmark. Comparative quantitative systems pharmacology modeling of anti-PCSK9 therapeutic modalities in hypercholesterolemia. J Lipid Res. 2019 Sep; 60(9): 1610–1621. doi: 10.1194/jlr.M092486

Our team in collaboration with AstraZeneca developed an integrative systems pharmacology model of lipoprotein homeostasis which sets the stage for the quantitative benchmarking of two anti-PCSK9 pharmacological modality classes, monoclonal antibodies, and small interfering RNA, by describing in minimalistic yet mechanistic terms complex interactions between multiple plasma lipoprotein and lipid biomarkers, and by establishing a quantitative link between plasma PCSK9 and low-density lipoprotein cholesterol reduction for five different anti-PCSK9 compounds.