17/04/2024
A. Nikitich, G. Helmlinger, K. Peskov, G. Bocharov. (2024) Mathematical modeling of endogenous and exogenously administered T cell recirculation in mouse and its application to pharmacokinetic studies of cell therapies. Front. Immunol., Sec. T Cell Biology, 2024, 15:1357706 https://doi.org/10.3389/fimmu.2024.1357706
T cell migration in vivo has fascinated scientists for 60 years. T cell kinetics are important for understanding the immune response to infectious agents. More recently, adoptive T cell therapy has emerged as the most promising approach to treat a wide range of diseases, including autoimmune diseases and cancer, with characterization of cell kinetics representing an important step toward predicting therapeutic efficacy.
